Disease-First: A New Paradigm for Environmental Health Science Research
نویسندگان
چکیده
A murine model of spontaneous metastasis of mammary adenocarcinomas in mice was developed by serial transplantation of spontaneous BALB/cfC3H/Crgl tumours into the mammary gland. Through 8 transplant generations, 5 lines demonstrated maintenance of metastatic phenotype and consistent gross and histological morphology and growth properties. Tumour lines M12, M35, and M51 metastasized from the mammary gland with overall frequencies of 53, 80, and 85%, respectively. Line T5 was weakly metastatic, capable of a minor degree of lung colonization in 8% of hosts, while line WT2 failed to establish aniy grossly
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